A COMPREHENSIVE VALIDATION OF VERY EARLY RULE-OUT STRATEGIES FOR NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN EMERGENCY DEPARTMENTS: PROTOCOL FOR A MULTICENTRE PROSPECTIVE COHORT STUDY

A comprehensive validation of very early rule-out strategies for non-ST-segment elevation myocardial infarction in emergency departments: protocol for a multicentre prospective cohort study

Introduction Recent advances in troponin sensitivity enabled early and accurate judgement of ruling-out myocardial infarction, especially non-ST elevation myocardial infarction (NSTEMI) in emergency departments (EDs) with development of various prediction-rules and high-sensitive-troponin-based strategies (hs-troponin).Reliance on clinical impressi

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Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer.

PARP inhibitors target BRCA mutations and defective homologous recombination repair (HRR) for the treatment of epithelial ovarian cancer (EOC).However, the treatment of HRR-proficient EOC with PARP inhibitors remains challenging.The objective of this study was to determine whether the Seeds combination of triapine (ribonucleotide reductase inhibito

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